Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani

作者：Tanokashira Natsuki; Kukita Sanako; Kato Hikaru; Nehira Tatsuo; Angkouw Esther D; Mangindaan Remy E P; de Voogd Nicole J; Tsukamoto Sachiko^*

来源：Tetrahedron, 2016, 72(35): 5530-5540.

DOI：10.1016/j.tet.2016.07.045

• Marine sponge
• Petrosia alfiani
• Quinone
• USP7

We isolated 16 new xestoquinone derivatives, including two trimers, six dimers, and four monomers with containing thiomorpholine 1,1-dioxide and pyrrolidine-2,4-diol moieties, from the marine sponge Petrosia alfiani and determined their structures including the absolute configurations using computational methods. They exhibited potent inhibitory activities against USP7 with 1050 values in the range of 0.13-2.0 mu M.

• 出版日期2016-9-1