Lectin approaches for glycoproteomics in FDA-approved cancer biomarkers

作者：Badr Haitham A; AlSadek Dina M M; Darwish Ashraf A; ElSayed Abdelaleim I; Bekmanov Bakhytzhan O; Khussainova Elmira M; Zhang Xueji; Cho William C S; Djansugurova Leyla B; Li Chen Zhong^*

来源：Expert Review of Proteomics, 2014, 11(2): 227-236.

DOI：10.1586/14789450.2014.897611

• biomarkers
• cancer
• diagnosis
• glycoproteome
• lectins

The nine FDA-approved protein biomarkers for the diagnosis and management of cancer are approaching maturity, but their different glycosylation compositions relevant to early diagnosis still remain practically unexplored at the sub-glycoproteome scale. Lectins generally exhibit strong binding to specific sub-glycoproteome components and this property has been quite poorly addressed as the basis for the early diagnosis methods. Here, we discuss some glycoproteome issues that make tackling the glycoproteome particularly challenging in the cancer biomarkers field and include a brief view for next generation technologies.

• 出版日期2014-4
• 单位北京科技大学