Mutations in glucocerebrosidase are a major genetic risk factor for Parkinson's disease and increase susceptibility to dementia in a Flanders-Belgian cohort

作者：Crosiers David^*; Verstraeten Aline; Wauters Eline; Engelborghs Sebastiaan; Peeters Karin; Mattheijssens Maria; De Deyn Peter P; Theuns Jessie; Van Broeckhoven Christine; Cras Patrick

来源：Neuroscience Letters, 2016, 629: 160-164.

DOI：10.1016/j.neulet.2016.07.008

• Parkinson's disease
• Glucocerebrosidase
• GBA
• Genotype-phenotype correlation

Objective: To investigate the frequency of glucocerebrosidase (GBA) mutations in a Flanders-Belgian Parkinson's disease (PD) patient cohort and to assess genotype-phenotype correlations.
Methods: We performed an in-depth sequencing of all coding exons of GBA in 266 clinically well characterized PD patients and 536 healthy control individuals.
Results: We identified rare, heterozygous GBA mutations in 12 PD patients (4.5%) and in 2 healthy control individuals (0.37%), confirming the genetic association of GBA mutations with PD in the Flanders-Belgian population (p < 0.001). The patient carriers had a more severe Unified Parkinson's Disease Rating Scale (UPDRS) motor score than non-carriers. Also, GBA mutation status was a significant, independent predictor for the presence of dementia (OR = 12.43, 95% CI: 2.27-68.14. p = 0.004). Genetic association of PD with the common p.E326K and p.T369M variants in GBA was absent.
Conclusion: In our Flanders-Belgian cohort, carrier status of a heterozygous GBA mutation was a strong genetic risk factor for PD. The GBA mutation frequency of 4.5% is comparable to previously reported data in other European PD patient cohorts. Furthermore, our clinical data suggest a more severe motor phenotype and a strong predisposition to dementia in GBA mutation carriers.

• 出版日期2016-8-26