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摘要
Acid-catalyzed Nazarov reaction of beta-alkoxy divinyl ketones providing 5-oxycyclopent-2-enones has been developed. The effects of the beta-alkoxy group on the catalyst efficiency and the regioselectivity are based on the stabilization of the intermediates and the spontaneous elimination of the group followed by trapping. The substrates are easily accessible using the torquoselective oleflnation of esters with ynolates.
- 出版日期2007-4-24
