Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis: A case control study

作者：Nordholm Dorte; Poulsen Henrik Enghusen; Hjorthoj Carsten; Randers Lasse; Nielsen Mette O; Wulff Sanne; Krakauer Kristine; Norbak Emig Henrik; Henriksen Trine; Glenthoj Birte; Nordentoft Merete

来源：Psychiatry Research, 2016, 241: 201-206.

DOI：10.1016/j.psychres.2016.04.062

It has been suggested that patients with schizophrenia develop higher levels of oxidative stress, which may contribute to deteriorating mental illness. In order to examine oxidative stress in the early stages of severe mental illness, we examined the levels of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, perceived stress and recent life events in patients at ultra high-risk (UHR) of developing psychosis, in antipsychotic naive patients with first-episode schizophrenia (FES), and in healthy controls. We included 41 UHR patients, 35 FES patients, and 29 healthy controls. There was no difference in the level of DNA/RNA oxidative damage between UHR patients and FES patients compared with healthy controls. We found no association between levels of DNA/RNA oxidative damage and perceived stress/life events. Based on the results, we suggest that DNA and RNA oxidative markers are not increased during the early stages of illness,. but further longitudinal studies in first-episode psychosis should be carried out to examine whether DNA and RNA oxidative damage are potential markers of severe illness.

• 出版日期2016-7-30
• 单位上海市精神卫生中心