Comparison of Outcomes in Patients with Early-stage Mucinous Endometrial Cancer and Those with Endometrioid Endometrial Cancer, With and Without Adjuvant Therapy

作者：Owusu Darko Sharon; Rauh Hain J Alejandro; Horowitz Neil S; Goodman Annekathryn; Schorge John O; del Carmen Marcela G^*

来源：Journal of Reproductive Medicine, 2014, 59(11-12): 527-533.

• endometrial cancer
• endometrioid endometrial cancer
• gynecological malignancies
• hyperestrogenism
• mucinous endometrial cancer

OBJECTIVE: To compare risk factors, treatment, and outcomes in patients with stage I/II mucinous endometrial cancer (MEC) relative to those of patients with endometrioid endometrial cancer (EEC).
STUDY DESIGN: We conducted a case-control study of patients with MEC and EEC. Patients with stage IA, IB, or II MEC treated at the 2 institutions between 01/01/ 1996 and 01/01/2007 were identified. Each MEC case was matched with 2 EEC controls by age, stage, grade, and year of diagnosis. The Kaplan-Meier method was used to generate overall survival (OS) data. Factors predictive of outcome were compared using the log-rank test and Cox proportional hazards model.
RESULTS: A total of 34 patients with MEC were compared to 68 controls with EEC. All patients were treated by hysterectomy and bilateral salpingo-oophorectomy. Use of adjuvant radiation therapy was similar between cases and controls. The 5-year disease-free survival (DFS) rates were not significantly different in patients with MEC when compared to those with EEC (89% vs. 92%, respectively, p =0.2). The 5-year OS rates for patients with MEC and the control group were 95% and 96%, respectively (p =0.1).
CONCLUSION: Patients with early-stage MEC and EEC have similar DFS and overall survival.

• 出版日期2014-12