Systemic Immune-Inflammation Index and Circulating T-Cell Immune Index Predict Outcomes in High-Risk Acral Melanoma Patients Treated with High-Dose Interferon

作者：Yu, Jiayi; Wu, Xiaowen; Yu, Huan; Li, Siming; Mao, Lili; Chi, Zhihong; Si, Lu; Sheng, Xinan; Cui, Chuanliang; Dai, Jie; Ma, Meng; Tang, Huan; Xu, Tianxiao; Yan, Junya; Kong, Yan^*; Guo, Jun^*

来源：Translational Oncology, 2017, 10(5): 719-725.

DOI：10.1016/j.tranon.2017.06.004

• METASTATIC MELANOMA
• CUTANEOUS MELANOMA
• LYMPHOCYTE RATIO
• CANCER
• SURVIVAL
• NEUTROPHIL
• TRIAL
• THERAPY
• ROLES

High-dose interferon alfa-2b (IFN-alpha-2b) improves the survival of patients with high-risk melanoma. We aimed to identify baseline peripheral blood biomarkers to predict the outcome of acral melanoma patients treated with IFN-alpha-2b. Pretreatment baseline parameters and clinical data were assessed in 226 patients with acral melanoma. Relapse-free survival (RFS) and overall survival (OS) were assessed using the Kaplan-Meier method, and multivariate Cox regression analyses were applied after adjusting for stage, lactate dehydrogenase (LDH), and ulceration. Univariate analysis showed that neutrophil-to-lymphocyte ratio >= 2.35, platelet-to-lymphocyte ratio >= 129, systemic immune-inflammation index (SII)>= 615x10(9)/l,and elevated LDH were significantly associated with poor RFS and OS. The SII is calculated as follows: platelet count x neutrophil count/lymphocyte count. On multivariate analysis, the SII was associated with RFS [hazard ratio (HR)=1.661, 95% confidence interval (CI): 1.066-2.586, P=.025] and OS(HR=2.071, 95% CI: 1.204-3.564, P=.009). Additionally, we developed a novel circulating T-cell immune index (CTII) calculated as follows: cytotoxic T lymphocytes/(CD4(+) regulatory T cells x CD8(+) regulatory T cells). On univariate analysis, the CTII was associated with OS (HR=1.73, 95% CI: 1.01-2.94, P=.044). The SII and CTII might serve as prognostic indicators in acral melanoma patients treated with IFN-alpha-2b. The indexes are easily obtainable via routine tests in clinical practice.

• 出版日期2017-10
• 单位北京大学