Association Between rs2981582 Polymorphism in the FGFR2 Gene and the Risk of Breast Cancer in Mexican Women

作者：Murillo Zamora Efren; Moreno Macias Hortensia; Ziv Elad; Romieu Isabelle; Lazcano Ponce Eduardo; Angeles Llerenas Angelica; Perez Rodriguez Edelmiro; Vidal Millan Silvia; Fejerman Laura; Torres Mejia Gabriela^*

来源：Archives of Medical Research, 2013, 44(6): 459-466.

DOI：10.1016/j.arcmed.2013.08.006

• rs2981582 single nucleotide polymorphism
• FGFR2 gene
• Breast cancer

Background and Aims. The rs2981582 single nucleotide polymorphism in the fibroblast growth factor receptor 2 gene has been consistently associated with an increased risk of breast cancer. We evaluated the effect of rs2981582 polymorphism in the FGFR2 gene on the risk of breast cancer and its interaction with non-genetic risk factors.
Methods. A population-based case-control study was conducted in Mexico. Data from 687 cases and 907 controls were analyzed.
Results. The T allele of the rs2981582 polymorphism was associated with an increased risk of breast cancer (ORper allele = 1.24, 95% CI 1.06-1.46). There was also an interaction between this polymorphism and alcohol consumption (p = 0.043). The effect of alcohol consumption on the risk of breast cancer varied according to the allelic variants of the rs2981582 polymorphism in the FGFR2 gene: OR = 3.97 (95% CI 2.10-7.49), OR = 2.01 (95% CI 1.23-3.29) and OR = 1.21 (95% CI 0.48-3.05) for genotypes CC, CT and TT, respectively.
Conclusions. This is the first study exploring the association between rs2981582 polymorphism in the FGFR2 gene and breast cancer risk in Mexican women. The interaction found may be of great public health interest because alcohol consumption is a modifiable breast cancer risk factor. Therefore, replication of this finding is of foremost importance.