A major subgroup of Beijing family Mycobacterium tuberculosis is associated with multidrug resistance and increased transmissibility

作者：Hu Y; Ma X; Graviss E A; Wang W; Jiang W; Xu B^*

来源：Epidemiology and Infection, 2011, 139(1): 130-138.

DOI：10.1017/S0950268810000890

• Beijing family
• IS6110 restriction fragment length polymorphism
• mycobacterial interspersed repetitive units
• Mycobacterium tuberculosis
• spoligotyping

This study investigated further the association between the Beijing family Mycobacterium tuberculosis circulating in rural China and anti-tuberculosis (TB) drug resistance. In total, 351 M. tuberculosis isolates were collected through a population-based epidemiological study, 223 (63.5%) of which were resistant to at least one anti-TB drug, including 53 (15.1%) multidrug-resistant (MDR) isolates. Spoligotyping found 243 isolates (69.2%) that belonged to the Beijing family. A major subgroup of the Beijing family identified by mycobacterial interspersed repetitive unit (MIRU) genotyping (223325173533), showed significantly higher frequencies of MDR (44.7% vs. 13.7%, OR 6.18, 95% CI 2.68-14.23), katG and rpoB mutations (31.6% vs. 9.3%, OR 4.27, 95% CI 1.86-9.80), and being clustered by IS6110 RFLP genotyping (60.5% vs. 21.0%, OR 6.14, 95% CI 2.82-13.37) in comparison with other Beijing family isolates. Our data suggest that MIRU genotype 223325173533 of the Beijing family is associated with MDR and increased transmissibility.

• 出版日期2011-1
• 单位复旦大学