科研之友
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摘要
While the cholesterol-lowering efficacy of plant sterols (PS) is known, issues surrounding reduced PS solubility of some dietary formulations remain to be elucidated. This study determined the efficacy of a water dispersible formulation of free plant sterols (WD-PS) versus plant sterol esters (PS-esters). Forty-seven mild-to-moderately hypercholesterolemic individuals in a randomized, crossover study were provided for 4 wk with a single-dose daily regimen of PS-enriched yogurt (2 g/d of PS from WD-PS or PS-esters) or placebo. Yogurt enriched with WD-PS or PS-esters induced similar decreases in serum total (7.7% and 6.3%, respectively) and LDL cholesterol levels (11.7% and 11.6%, respectively), as percentage relative to the control (p < 0.001; all). Ratios of total to HDL cholesterol and non-HDL to HDL cholesterol decreased more (p < 0.05) with WD-PS (10.6% and 15.2%, respectively) than with PS-esters (7.0% and 10.8%, respectively) compared with control. Consumption of WD-PS reduced serum triglyceride levels (13.9%, p < 0.05) compared to consumption of PS-esters (0.6%). Both WD-PS and PS-esters contributed effectively to LDL cholesterol lowering, however, the formulation of WD-PS yield additional effects on preventing cardiovascular diseases by improving serum TG and the ratio of total to HDL cholesterol.
- 出版日期2014-1
