Steroidal glycosides from the underground parts of Yucca glauca and their cytotoxic activities

作者：Yokosuka Akihito^*; Suzuki Tomoka; Tatsuno Satoru; Mimaki Yoshihiro

来源：Phytochemistry, 2014, 101: 109-115.

DOI：10.1016/j.phytochem.2014.02.002

• Soapweed
• Yucca glauca
• Agavaceae
• Steroidal glycosides
• Spirostanol glycosides
• Furostanol glycosides
• HL-60 cells
• A549 cells
• Apoptosis

Six steroidal glycosides and 14 known compounds were isolated from the underground parts of Yucca glauca (Agavaceae). Their structures were determined from extensive spectroscopic analysis, including analysis of two-dimensional NMR data, and from chemical transformations. The compounds were also evaluated for cytotoxic activities against HL-60 human leukemia cells and A549 human lung adenocarcinoma cells. Four spirostanol glycosides and three furostanol glycosides exhibited cytotoxic activities against both HL-60 and A549 cells. Two of the compounds induced apoptosis in HL-60 cells.

• 出版日期2014-5