Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis

作者：Mo, Cuiju; Peng, Qiliu; Sui, Jingzhe; Wang, Jian; Deng, Yan; Xie, Li; Li, Taijie; He, Yu; Qin, Xue^*; Li, Shan

来源：BMC Neurology, 2014, 14(1): 13.

DOI：10.1186/1471-2377-14-13

• Cathepsin D
• AD
• Polymorphism
• Meta-analysis

Background: Cathepsin D C224T polymorphism has been reported to associate with AD susceptibility. But the results were inconsistent. This study aimed to assess the relationship between C224T polymorphism and AD risk.
Methods: The relevant studies were identified by searching PubMed, Embase, Web of Science, Google Scholar and Wan fang electronic databases updated on July 2013. The relationship between Cathepsin D C224T polymorphism and AD risk was evaluated by ORs and 95% CIs.
Results: A total of 25 case-control studies including 5,602 cases and 11,049 controls were included in the meta-analysis. There was no association between C224T polymorphism and AD risk with all the studies were pooled in the meta-analysis (CT vs. CC: OR = 1.125, 95% CI = 0.974-1.299, P = 0.109; CT + TT vs. CC: OR = 1.136, 95% CI = 0.978-1.320, P = 0.094). Furthermore, when stratified by ethnicity, age of onset and APOE epsilon 4 status, significant association did not found in all subgroups.
Conclusion: The present meta-analysis suggested that the Cathepsin D C224T polymorphism was not associated with AD susceptibility.

• 出版日期2014-1-15
• 单位广西医科大学