Angiotensin-(1-7) attenuates hypertension in exercise-trained renal hypertensive rats

作者：Shah Amin; Oh Young Bin; Lee Sun Hwa; Lim Jung Min; Kim Suhn Hee^*

来源：American Journal of Physiology - Heart and Circulatory Physiology, 2012, 302(11): H2372-H2380.

DOI：10.1152/ajpheart.00846.2011

• swimming exercise training
• atrial natriuretic peptide
• cardiac hypertrophy
• Mas receptor

Shah A, Oh YB, Lee SH, Lim JM, Kim SH. Angiotensin-(1-7) attenuates hypertension in exercise-trained renal hypertensive rats. Am J Physiol Heart Circ Physiol 302: H2372-H2380, 2012. First published March 30, 2012; doi:10.1152/ajpheart.00846.2011.-Angiotensin-( 1-7) [ ANG-(1-7)] plays a counterregulatory role to angiotensin II in the renin-angiotensin system. In trained spontaneous hypertensive rats, Mas expression and protein are upregulated in ventricular tissue. Therefore, we examined the role of ANG-(1-7) on cardiac hemodynamics, cardiac functions, and cardiac remodeling in trained two-kidney one-clip hypertensive (2K1C) rats. For this purpose, rats were divided into sedentary and trained groups. Each group consists of sham and 2K1C rats with and without ANG-(1-7) infusion. Swimming training was performed for 1 h/day, 5 days/wk for 4 wk following 1 wk of swimming training for acclimatization. 2K1C rats showed moderate hypertension and left ventricular hypertrophy without changing left ventricular function. Chronic infusion of ANG-(1-7) attenuated hypertension and cardiac hypertrophy only in trained 2K1C rats but not in sedentary 2K1C rats. Chronic ANG-(1-7) treatment significantly attenuated increases in myocyte diameter and cardiac fibrosis induced by hypertension in only trained 2K1C rats. The Mas receptor, ANG II type 2 receptor protein, and endothelial nitric oxide synthase phosphorylation in ventricles were upregulated in trained 2K1C rats. In conclusion, chronic infusion of ANG-(1-7) attenuates hypertension in trained 2K1C rats.

• 出版日期2012-6