Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury

作者：Fee Dominic B^*; Swartz Karin R; Scheff Nicole; Roberts Kelly; Gabbita Prasad; Scheff Stephen

来源：Brain Research, 2010, 1340: 81-85.

DOI：10.1016/j.brainres.2010.04.047

• beta-Methyl-6-chloromelatonin
• Melatonin analog
• Spinal cord injury
• Contusional injury

Spinal cord injury (SCI) is a devastating condition. Melatonin supplementation has been shown to lessen SCI, but its use has been limited by its side effect profile. In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10 mg/kg or 100 mg/kg supplementation. The 10 mg/kg supplementation demonstrated benefit; the 100 mg/kg dosage was limited by toxicity. This is the first work to assess a melatonin analog in SCI.

• 出版日期2010-6-22