MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B

作者：Sun, Peng; Zhang, Dan; Huang, Haiping; Yu, Yafeng; Yang, Zhendong; Niu, Yuyu; Liu, Jisheng^*

来源：Biological Chemistry, 2019, 400(2): 237-246.

DOI：10.1515/hsz-2018-0265

• CDC14B
• cell cycle
• cell death
• laryngeal cancer
• miR-1225-5p

This study aimed to investigate the role of miRNA-1225-5p (miR-1225) in laryngeal carcinoma (LC). We found that the expression of miR-1225 was suppressed in human LC samples, while CDC14B (cell division cycle 14B) expression was reinforced in comparison with surrounding normal tissues. We also demonstrated that enhanced expression of miR-1225 impaired the proliferation and survival of LC cells, and resulted in G1/S cell cycle arrest. In contrast, reduced expression of miR-1225 promoted cell survival. Moreover, miR-1225 resulted in G1/S cell cycle arrest and enhanced cell death. Further, miR-1225 targets CDC14B 3'-UTR and recovery of CDC14B expression counteracted the suppressive influence of miR-1225 on LC cells. Thus, these findings offer insight into the biological and molecular mechanisms behind the development of LC.

• 出版日期2019-2
• 单位苏州大学