Efficient one-pot synthesis of novel and diverse tetrahydroquinolines bearing pyranopyrazoles using organocatalyzed domino Knoevenagel/hetero Diels-Alder reactions

作者：Pandit Rameshwar Prasad; Lee Yong Rok^*

来源：Molecular Diversity, 2014, 18(1): 39-50.

DOI：10.1007/s11030-013-9482-6

• Tetrahydroquinolines
• Pyrazolones
• Aminoaldehydes
• Knoevenagel condensation
• Hetero Diels-Alder reaction

A new synthetic route to biologically interesting diverse tetrahydroquinolines bearing pyranopyrazoles was developed by reacting pyrazolones and ,-dialkylated aminobenzaldehydes in the presence of EDDA. The key strategy underlying the methodology used was the domino Knoevenagel/hetero Diels-Alder reaction. This synthetic method provides a variety of novel tetrahydroquinolines in good yields.

• 出版日期2014-2