A Rapid Click Chemistry Using Beta-Cyclodextrin Immobilized on Glass Micro-Particles

作者：Tahir Muhammad Nazir; Qamar Riaz ul; Mischnick Petra; Kim Jaebum; Jung Seunho^*

来源：Letters in Organic Chemistry, 2013, 10(4): 269-276.

• beta-Cyclodextrin
• click chemistry
• glass micro-particles
• phase transfer catalyst
• surface functionalization

The surface of glass micro-particle (GMP) was functionalized with beta-cyclodextrin (-%26gt; GMP-beta-CD) and was characterized by X-ray photoelectron spectroscopy (XPS). GMP-beta-CD was used as a phase transfer catalyst for click reactions of aromatic azides with terminal acetylenes. For click reaction of benzyl azide and phenyl acetylene, reaction time was decreased from 5.8 h to 10 min when 0.8g GMP-beta-CD /mmol of benzyl azide was added. The modified surface of GMP-beta-CD showed no change or degradation after repeated use as confirmed from XPS analysis after 10 cycles.

• 出版日期2013-5