Body Mass Index and Adverse Outcomes in Elderly Patients With Atrial Fibrillation The AMADEUS Trial

作者：Senoo Keitaro; Lip Gregory Y H^*

来源：Stroke, 2016, 47(2): 523-526.

DOI：10.1161/STROKEAHA.115.011876

• atrial fibrillation
• international normalized ratio
• mortality
• obesity
• stroke

Background and Purpose-Obesity has been associated with increased cardiovascular risk in atrial fibrillation, but little is known in elderly patients with atrial fibrillation.
Methods-Post hoc analysis of data from the AMADEUS (Evaluating the Use of SR34006 Compared to Warfarin or Acenocoumarol in Patients With Atrial Fibrillation) trial.
Results-We studied 1588 elderly patients, who were categorized as normal body mass index (BMI, 18.5-25 kg/m(2); n=515 [32.4%]), overweight (BMI, 25-30 kg/m(2); n=711 [44.8%]), and obese (BMI >= 30 kg/m(2); n=362 [22.8%]). There was a significant reduction in the composite outcome of cardiovascular death and stroke/systemic embolism with increasing BMI category, being 5.0%, 3.2%, and 1.5% per 100 patient-years, respectively (P for trend=0.01). Cox proportional hazards analysis found obesity to be associated with a lower risk of the primary composite outcome (hazard ratio, 0.29; 95% confidence interval, 0.11-0.77; P=0.01). In the warfarin arm (n=814), multivariate logistic regression analysis demonstrated that obesity was independently related to higher odds of time in therapeutic range >= 60% (odds ratio, 1.84; 95% confidence interval, 1.21-2.80; P=0.004).
Conclusion-Obesity was associated with a lower stroke and mortality rate in elderly anticoagulated atrial fibrillation patients. Obesity was related to good quality anticoagulation control.

• 出版日期2016-2