Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans

作者：Sallusto Federica^*; Cassotta Antonino; Hoces Daniel; Foglierini Mathilde; Lanzavecchia Antonio

来源：Cold Spring Harbor Perspectives in Biology, 2018, 10(3): a029421.

DOI：10.1101/cshperspect.a029421

The wide range of effector and memory T cells is instrumental for immune regulation and tailored mechanisms of protection against pathogens. Here, we will focus on human CD4 T cells and discuss T-cell plasticity and intraclonal diversification in the context of a progressive and selective model of CD4 T-cell differentiation.

• 出版日期2018-3