Application of Poly-L-Lactic Acid Nanosheet as a Material for Wound Dressing

作者：Aoki Shimpo; Kinoshita Manabu^*; Miyazaki Hiromi; Saito Akihiro; Fujie Toshinori; Iwaya Keiichi; Takeoka Shinji; Saitoh Daizoh

来源：Plastic and Reconstructive Surgery, 2013, 131(2): 236-240.

DOI：10.1097/PRS.0b013e3182789c79

The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing. (Plast. Reconstr. Surg. 131: 236, 2013.)

• 出版日期2013-2