Delayed gadolinium-enhanced MRI of the fibrocartilage disc of the temporomandibular joint - a feasibility study

作者：Pittschieler Elisabeth^*; Szomolanyi Pavol; Schmid Schwap Martina; Weber Michael; Egerbacher Monika; Traxler Hannes; Trattnig Siegfried

来源：Magnetic Resonance Imaging, 2014, 32(10): 1223-1229.

DOI：10.1016/j.mri.2014.08.008

• dGEMRIC
• Temporomandibular joint
• Fibrocartilage disc
• MRI at 3 T
• Glycosaminoglycan in temporomandibular joint

Objective: To 1) test the feasibility of delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) at 3 Tin the temporomandibular joint (TMJ) and 2) to determine the optimal delay for measurements of the TMJ disc after i.v. contrast agent (CA) administration. %26lt;br%26gt;Design: MRI of the right and left TMJ of six asymptomatic volunteers was performed at 3 T using a dedicated coil. 2D inversion recovery (2D-IR) sequences were performed at 4 time points covering 120 minutes and 3D gradient-echo (3D GRE) dual flip-angle sequences were performed at 14 time points covering 130 minutes after the administration of 0.2 mmol/kg of Gd-diethylenetriamine pentaacetic acid ion (Gd-DTPA)(2-), i.e., 0.4 mL of Magnevist(TM) per kg body weight. Pair-wise tests were used to assess differences between pre-and post-contrast T1 values. %26lt;br%26gt;Results: 2D-IR sequences showed a statistically significant drop (p %26lt; 0.001) in T1 values after i.v. CA administration. The T1 drop of 50% was reached 60 minutes after bolus injection in the TMJ disc. The 3D GRE dual flip-angle sequences confirmed these results and show plateau of T1 after 60 minutes. %26lt;br%26gt;Conclusions: T1 (Gd) maps calculated from dGEMRIC data allow in vivo assessment of the fibrocartilage disc of the TMJ. The recommended measurement time for dGEMRIC in the TMJ after iv. CA administration is from 60 to 120 minutes.

• 出版日期2014-12