Development of a carbon nanotube paste electrode modified with zinc phosphate for captopril determination in pharmaceutical and biological samples

作者：Janegitz Bruno C; Figueiredo Filho Luiz C S; Vicentini Fernando Campanha; Ribeiro Maria Fernanda M; Suarez Willian T; Fatibello Filho Orlando; Metters Jonathan P; Banks Craig E^*

来源：Analytical Methods, 2014, 6(5): 1324-1329.

DOI：10.1039/c3ay42220h

We report a novel electrode composite comprising zinc phosphate within a multiwalled carbon nanotube paste electrode matrix which is applied for the detection of trace amounts of captopril (CAP) via square-wave adsorptive anodic stripping voltammetry (SWAdASV); to the best of our knowledge this is the first report on such a composite electrode. Under optimum experimental conditions, the peak current of CAP was found to be linear over the concentration range from 3.7 to 67 mu mol L-1 with a limit of detection of 0.1 mu mol L-1. The proposed method was applied for the successful determination of CAP in commercial tablet excipients and biological samples using the electroanalytical protocol evaluated against the laboratory standard iodometric procedure. Excellent comparability between the two is found suggesting that the former can replace the latter within laboratory settings or can be applied to in-the-field applications.

• 出版日期2014