Protein segregase meddles in remodeling of mRNA-protein complexes

作者：Chen Chyi Ying A; Shyu Ann Bin^*

来源：Genes & Development, 2013, 27(9): 980-984.

DOI：10.1101/gad.219469.113

• HuR
• mRNA stability
• ubiquitin

Remodeling of RNA-protein complexes (mRNPs) plays a critical role in mRNA biogenesis and metabolism. However, relatively little is known about the underlying mechanism and regulation of the mRNP remodeling. In this issue of Genes & Development, Zhou and colleagues (pp. 1046-1058) report that a protein remodeling machine, the p97-UBXD8 complex, disassembles mRNPs containing the AU-rich elements (AREs) bound by HuR proteins in a nondegradative, ubiquitin signaling-dependent manner, revealing a novel mechanism to regulate mRNA turnover.

• 出版日期2013-5-1