Assessing immunologic risk factors in transplantation

作者：Philogene Mary Carmelle^*; Zachary Andrea A

来源：Expert Review of Clinical Immunology, 2013, 9(8): 773-779.

DOI：10.1586/1744666X.2013.814413

• anamnestic response
• antibody-mediated rejection
• chronic rejection
• DSA
• graft survival
• noninherited maternal antigen proinflammatory cytokines
• risk assessment
• sensitization

The innate and adaptive immune systems, together, represent the largest impediment to good and long-lasting graft function. Although improved immunosuppressive agents and expanded and enhanced diagnostic tools have led to better prevention and treatment of acute rejection, chronic rejection remains a serious threat to long-term graft survival. Immunologic heterogeneity among patients, variability in treatment protocols and unforeseen events following transplantation translate into different levels of risk among patients. While one cannot predict with certainty the short- and long-term outcomes of a particular transplant, it is possible to identify immunologic risk factors that can affect outcome.

• 出版日期2013-8