科研之友
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摘要
In this study we resequenced 1729bp of the rabbit melanocortin 4 receptor (MC4R) gene in 31 rabbits from different breeds/lines and identified ten polymorphisms: one was an indel and 9 were single nucleotide polymorphisms (SNPs). The indel and 5 SNPs were in the 5-flanking region, 3 were synonymous SNPs and one was a missense mutation (c.101G%26gt;A; p.G34D), located in a conserved position of the extracellular tail of the MC4R protein. The missense mutation was analyzed in a panel of 74 rabbits of different breeds and in 516 performance tested rabbits of a commercial paternal line under selection for growth efficiency. Association analysis indicated that rabbits with the less frequent genotype in this population (DD) had a lighter weight at 70 postnatal days than animals with genotype GD (P%26lt;0.10) and animals with genotype GG (P%26lt;0.05). This is the third study on candidate genes, after those on GH1 and IGF2 that reported a marker associated with finishing weight. Therefore, it seems that a candidate gene approach in rabbit based on previous information accumulated in other livestock species could be useful to identify genes explaining a fraction of variability of performance traits with potential application on rabbit breeding and selection.
- 出版日期2013-10-2
