Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury

作者：Liu, Yange; Wang, Juan; Li, Lanzhou; Hu, Wenji; Qu, Yidi; Ding, Yipei; Meng, Lina; Teng, Lirong^*; Wang, Di^*

来源：Oxidative Medicine and Cellular Longevity, 2017, 2017: 7841823.

DOI：10.1155/2017/7841823

• NF-KAPPA-B
• SUBMERGED CULTURE
• INDUCED APOPTOSIS
• CELL APOPTOSIS
• INHIBITION
• PATHWAY
• DAMAGE
• MICE
• AUTOPHAGY
• PROTECTS

In the present study, the components of A. cinnamomea (AC) mycelia were systematically analyzed. Subsequently, its hepatoprotective effects and the underlying mechanisms were explored using a mouse model of acute alcohol-induced liver injury. AC contained 25 types of fatty acid, 16 types of amino acid, 3 types of nucleotide, and 8 types of mineral. The hepatoprotective effects were observed after 2 weeks of AC treatment at doses of 75mg/kg, 225mg/kg, and 675mg/kg in the mouse model. These effects were indicated by the changes in the levels of aspartate aminotransferase, alanine aminotransferase, several oxidation-related factors, and inflammatory cytokines in serum and/or liver samples. AC reduced the incidence rate of necrosis, inflammatory infiltration, fatty droplets formation, and cell apoptosis in liver detecting via histological and TUNEL assay. In addition, AC reduced the expression of cleaved caspase-3, -8, and -9 and the levels of phosphor-protein kinase B (Akt) and phosphor-nuclear factor-kappa B (NF-kappa B) in the liver samples. Collectively, AC-mediated hepatoprotective effects in a mouse model of acute alcohol-induced liver injury are the result of reduction in oxidative stress. This may be associated with Akt/NF-kappa B signaling. These results provide valuable evidence to support the use of A. cinnamomea as a functional food and/or medicine.

• 出版日期2017
• 单位吉林大学