Limitations of respiratory muscle and vastus lateralis blood flow during continuous exercise

作者：Henderson William R^*; Guenette Jordan A; Dominelli Paolo B; Griesdale Donald E G; Querido Jordan S; Boushel Robert; Sheel A William

来源：Respiratory Physiology & Neurobiology, 2012, 181(3): 302-307.

DOI：10.1016/j.resp.2012.04.001

• Cycle exercise
• Near infrared spectroscopy
• Ventilation
• Work of breathing

Measurement of regional blood flow to the respiratory muscles has traditionally been invasive. The blood flow index (BFI). a minimally invasive method using indocyanine green dye (ICG) and near infrared spectroscopy, allows assessment of within subject changes in regional blood flow. This study assessed regional BR to the vastus lateralis muscle (QBFI) and the superficial respiratory muscles in the seventh intercostal space (RMBFI). Eight healthy subjects cycled continuously at incrementally more difficulty stages to exhaustion. In our subjects. QBFI declined between 83% and 100% of maximal exertion (p = 0.002) and no statistically significant changes in RMBFI were seen despite steadily increasing ventilatory workloads. Post hoc pairwise comparisons demonstrated that QBFI at 83% work (0.015 mu moles s(-1) +/- 0.005) was significantly higher than at maximum work output (0.011 mu moles s(-1) +/- 0.004, p = 0.007). There were no other significant differences of QBFI between maximum work output and different levels of work. The current study suggests that respiratory and locomotor muscle blood flow during sub-maximal and maximal exertion is unable to match increasing workloads.

• 出版日期2012-5-31