An Essential Role for Liver ER alpha in Coupling Hepatic Metabolism to the Reproductive Cycle

作者：Della Torre Sara; Mitro Nico; Fontana Roberta; Gomaraschi Monica; Favari Elda; Recordati Camilla; Lolli Federica; Quagliarini Fabiana; Meda Clara; Ohlsson Claes; Crestani Maurizio; Uhlenhaut Nina Henriette; Calabresi Laura; Maggi Adriana^*

来源：Cell Reports, 2016, 15(2): 360-371.

DOI：10.1016/j.celrep.2016.03.019

Lipoprotein synthesis is controlled by estrogens, but the exact mechanisms underpinning this regulation and the role of the hepatic estrogen receptor alpha (ER alpha) in cholesterol physiology are unclear. Utilizing a mouse model involving selective ablation of ER alpha in the liver, we demonstrate that hepatic ER alpha couples lipid metabolism to the reproductive cycle. We show that this receptor regulates the synthesis of cholesterol transport proteins, enzymes for lipoprotein remodeling, and receptors for cholesterol uptake. Additionally, ER alpha is indispensable during proestrus for the generation of high-density lipoproteins efficient in eliciting cholesterol efflux from macrophages. We propose that a specific interaction with liver X receptor alpha (LXR alpha) mediates the broad effects of ER alpha on the hepatic lipid metabolism.

• 出版日期2016-4-12
• 单位河北医科大学