A domino Ugi/Michael approach for the synthesis of alpha,beta-unsaturated gamma-lactams

作者：Li Zhenghua; Kumar Amit; Peshkov Anatoly; Van der Eycken Erik V^*

来源：Tetrahedron Letters, 2016, 57(7): 754-756.

DOI：10.1016/j.tetlet.2016.01.014

• Multicomponent reactions
• gamma-Lactams
• Domino reactions
• Synthetic method

A domino Ugi/Michael access to alpha,beta-unsaturated gamma-lactams has been elaborated. This protocol offers a simplistic assembly of a alpha,beta-unsaturated gamma-lactams in good yields starting from nitrogen-containing heterocyclic aldehydes, amines, 2-alkynoic acids, and isocyanides.

• 出版日期2016-2-17
• 单位KU Leuven