Antiarrhythmic activity of new 2-methoxyphenylpiperazine xanthone derivatives after ischemia/reperfusion in rats

作者：Rapacz Anna; Sapa Jacek; Pytka Karolina; Dudek Magdalena; Filipek Barbara; Szkaradek Natalia; Marona Henryk

来源：Pharmacological Reports, 2015, 67(6): 1163-1167.

DOI：10.1016/j.pharep.2015.03.011

• Xanthone derivatives
• Piperazine derivatives
• Antiarrhythmic
• Ischemia/reperfusion

Background: We have previously shown significant prophylactic and therapeutic antiarrhythmic activity in adrenaline-induced arrhythmia, as well as alpha(1)-adrenolytic properties of new derivatives of xanthone. Herein, we investigated their antiarrhythmic activity in the model of ischemia/reperfusion in isolated hearts. Furthermore, we assessed antioxidant activity in biochemical studies.
Methods: Antiarrhythmic activity in the model of ischemia/reperfusion in isolated perfused hearts was performed according to the Langendorff technique. Antioxidant activity was measured by lipid peroxidation level in tissue homogenate and in the FRAP assay.
Results: All studied compounds (MH-94, MH-99 and MH-105) showed significant antiarrhythmic activity in the model of ventricular arrhythmias associated with coronary artery occlusion and reperfusion. However, they did not demonstrate antioxidant effect, probably, because of the lack of free hydroxyl group(s) at a key position in the xanthone scaffold.
Conclusions: The present study provides evidences for antiarrhythmic activity of some 2-methoxyphenylpiperazine derivatives of xanthone.

• 出版日期2015