Autonomic dysfunction in presymptomatic and early symptomatic Huntington's disease

作者：Kobal J^*; Melik Z; Cankar K; Bajrovic F F; Meglic B; Peterlin B; Zaletel M

来源：Acta Neurologica Scandinavica, 2010, 121(6): 392-399.

DOI：10.1111/j.1600-0404.2009.01251.x

• autonomic dysfunction
• cold pressor test
• Huntington's disease
• simple mental arithmetic test

Objectives -
Although autonomic dysfunction was found in advanced Huntington's disease (HD) patients it is not clear whether there is autonomic dysfunction in presymptomatic and early symptomatic HD.
Material & methods -
Different cardiovascular autonomic tests were performed in 14 presymptomatic HD mutation carriers (PHD), 11 early symptomatic HD patients (EHD) and in 25 sex and age matched controls.
Results -
We found attenuated response to simple mental arithmetic test (relative heart rate in PHD and EHD was 10% lower than in controls; diastolic pressure was 10.6% lower in EHD than in controls; P < 0.05) and exaggerated response to the late phase of cold pressor test (relative heart rate was 10% higher in PHD and 7% higher in EHD than in controls; P < 0.05). The rest of the cardiovascular autonomic tests did not reveal significant differences between patients and controls.
Conclusions -
Our results suggest that subtle autonomic dysfunction occurs even in PHD and EHD.

• 出版日期2010-6
• 单位河北医科大学