Abnormal liver function test in hydatidiform moles: a retrospective study comparing the hyperthyroid state and the euthyroid state

作者：Kucukoglu Mehmet Emin; Dulger Ahmet Cumhur; Aslan Mehmet^*; Olmez Sehmus; Guler Ayse; Aldemir Mehmet Naci; Ebinc Senar; Karadas Sevdegul; Demirkiran Davut

来源：Gynecological Endocrinology, 2014, 30(4): 287-289.

DOI：10.3109/09513590.2013.875993

• beta-human chorionic gonadotropin
• complete mole
• gestational trophoblastic disease
• hydatidiform moles
• liver transaminases
• partial mole

Introduction: The effect of a hyperthyroid or euthyroid state on liver function tests in patients with hydatidiform moles (HM) is not known. The aim of this study was to determine the effect of hyperthyroidism on liver transaminases in HM.
Patients and methods: We retrospectively reviewed aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in 80 patients with HM (23 complete moles and 57 partial moles).
Results: Of the 80 HM patients, 52 (65%) were euthyroid and 28 (35%) were hyperthyroid. The number of gravida and the levels of serum beta-human chorionic gonadotropin (beta-HCG), AST, and ALT were significantly higher in the hyperthyroid state than in the euthyroid state (p = 0.033, p = 0.001, p = 0.001 and p = 0.001; respectively). Number of gravida, serum TSH and total T4 were significantly higher in complete HM than partial HM (p < 0.05, p < 0.001, p < 0.05; respectively).
Conclusions: Our results demonstrated that HM-related beta-HCG may activate thyroid cells via TSH-related signalling, resulting in the release of high levels of FT4, FT3, TT3 and TT4, and a subsequent decrease in TSH.

• 出版日期2014-4