Antimalarial and antitubercular C-glycosylated benz[alpha]anthraquinones from the marine-derived Streptomyces sp BCC45596

作者：Supong Khomsan; Thawai Chitti; Suwanborirux Khanit; Choowong Wilunda; Supothina Sumalee; Pittayakhajonwut Pattama^*

来源：Phytochemistry Letters, 2012, 5(3): 651-656.

DOI：10.1016/j.phytol.2012.06.015

• Streptomyces
• Benz[alpha]anthraquinones
• Urdamycinone
• Dehydroxyaquayamycin
• Antimalarial
• Anti-TB

Three naturally new C-glycosylated benz[alpha]anthraquinone derivatives, urdamycinone E (1), urdamycinone G (2), dehydroxyaquayamycin (3) have been isolated from the marine Streptomycetes sp. BCC45596. Urdamycin E (4), the possible biosynthetic precursor of 1-3, has also been identified after a recultivation of the strain. These compounds (1-4) exhibited potent anti-Plasmodium palcifarum K1 strain with IC50 values in a range of 0.0534-2.93 mu g/mL and anti-Mycobacterium tuberculosis with minimum inhibition concentrations (MICs) in a range of 3.13-12.50 mu g/mL. Cytotoxicity against KB, MCF-7, NCI-H187, and Vero cells was also evaluated.

• 出版日期2012-9