A new approach to high-shear mixer granulation using positron emission particle tracking

作者：Saito Yoshitoshi^*; Fan Xianfeng; Ingram Andy; Seville Jonathan Peter Kyle

来源：Chemical Engineering Science, 2011, 66(4): 563-569.

DOI：10.1016/j.ces.2010.09.028

• Granulation
• Particle processing
• Powder technology
• Visualization
• High-shear mixer
• Positron emission particle tracking

Positron emission particle tracking (PEPT) can provide quantitative information on particle motion in a mixer. For the first time, the present study clarifies the flow patterns of particles and granules during the process in which granules are formed in high-shear mixer granulation in three dimensions using PEPT. A number of different regions with size-dependent flows account for the variations in frequency and velocity of collisions between differently sized granules in the kernel when segregation occurs in the granulator. These findings offer a better understanding of the product properties and process attributes of high-shear mixer granulation, which will be of direct benefit as pharmaceutical and other products become more complex.

• 出版日期2011-2-15