A water soluble vitamin B-12-Re(I) fluorescent conjugate for cell uptake screens: use in the confirmation of cubilin in the lung cancer line A549

作者：Vortherms Anthony R; Kahkoska Anna R; Rabideau Amy E; Zubieta Jon; Andersen Louise Lund; Madsen Mette; Doyle Robert P^*

来源：Chemical communications, 2011, 47(35): 9792-9794.

DOI：10.1039/c1cc13615a

A water soluble vitamin B-12-rhenium conjugate was synthesized and used in concert with intrinsic factor to screen for cubilin receptor-mediated uptake in lung cancer cells. Internalization of the conjugate demonstrated that it could be used to rapidly screen for the cubilin receptor in living cells, subsequently confirmed with Western blotting and RT-PCR.

• 出版日期2011