Discovery of 2-(5-nitrothiazol-2-ylthio) benzo[d] thiazoles as novel c-Jun N-terminal kinase inhibitors

作者：De Surya K; Chen Li Hsing; Stebbins John L; Machleidt Thomas; Riel Mehan Megan; Dahl Russell; Chen Vida; Yuan Hongbin; Barile Elisa; Emdadi Aras; Murphy Ria; Pellecchia Maurizio^*

来源：Bioorganic & Medicinal Chemistry, 2009, 17(7): 2712-2717.

DOI：10.1016/j.bmc.2009.02.046

• JNK1
• JNK2
• JIP1
• DJNKI
• Allosteric kinase inbhibitors

A new series of 2-thioether-benzothiazoles has been synthesized and evaluated for JNK inhibition. The SAR studies led to the discovery of potent, allosteric JNK inhibitors with selectivity against p38.

• 出版日期2009-4-1
• 单位河北医科大学