Mitochondrial carriers and pores: Key regulators of the mitochondrial apoptotic program?

作者：Schwarz Michal; Andrade Navarro Miguel A; Gross Atan^*

来源：Apoptosis, 2007, 12(5): 869-876.

DOI：10.1007/s10495-007-0748-2

• apoptosis
• mitochondrial carrier proteins
• mitochondrial pores
• BCL-2 family members
• BID
• mitochondrial carrier homolog 2 (Mtch2)
• ADP/ATP translocase (ANT)
• voltage dependent anion channel (VDAC)

Mitochondria play a pivotal role in the process of apoptosis. Alterations in mitochondrial structure and function during apoptosis are regulated by proteins of the BCL-2 family, however their exact mechanism of action is largely unknown. Mitochondrial carriers and pores play an essential role in maintaining the normal function of mitochondria, and BCL-2 family members were shown to interact with several mitochondrial carriers/pores and to affect their function. This review focuses on the involvement of several of these mitochondrial carriers/pores in the regulation of the mitochondrial death pathway.

• 出版日期2007-5