Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A

作者：Chang Mou Nuo; Wang Hao; Gong Liu Zhu^*

来源：Organic Letters, 2011, 13(9): 2418-2421.

DOI：10.1021/ol200652j

The total synthesis of two diastereomers of spirotryprostatin A has been established starting with an asymmetric 1,3-dipolar cycloaddition of methyl 2-(2-nitrophenyl)acrylate with azomethine ylides catalyzed by a Bronsted acid.

• 出版日期2011-5-6
• 单位中国科学技术大学