Antinociceptive effects of A1 and A2 type botulinum toxins on carrageenan-induced hyperalgesia in rat

作者：Shin Min Chul; Yukihira Takashi; Ito Yushi; Akaike Norio^*

来源：Toxicon, 2013, 64: 12-19.

DOI：10.1016/j.toxicon.2012.12.011

• A2NTX
• A1LL
• Carrageenan
• c-Fos
• Pain

We performed a study on the antinociceptive effects of A1 and A2 type (A1LL and A2NTX, respectively) botulinum toxin on carrageenan-induced hyperalgesia in the rat. Both A1LL and A2NTX had antinociceptive effects in the carrageenan-induced inflammatory pain model, reducing the mechanical and thermal hyperalgesia. A2NTX also reduced the increase in c-fos immunoreactivity in L4-L5 spinal segments induced by carrageenan, suggesting that A2NTX inhibits the activation of spinal nociceptive afferent fibers that project to the CNS. Our results indicate that A2NTX may offer a new therapeutic tool to treat inflammatory pain.

• 出版日期2013-3-15