A genetic advance: lipoprotein(a) in aortic stenosis

作者：Yanagawa Bobby; Gupta Nandini; Verma Subodh^*

来源：Clinical Lipidology, 2013, 8(3): 307-309.

DOI：10.2217/CLP.13.25

• aortic stenosis
• genetics
• genome-wide association study
• Lp(a)
• pathogenesis

Thanassoulis et al. performed a genome-wide association study of 6924 patients to demonstrate an association between genetic variants in the gene encoding lipoprotein(a) (Lp(a)) and aortic valve calcification, as well as clinical aortic stenosis, a disease for which the only treatment is surgical or catheter-based valve replacement. Given the ethnic variability in Lp(a) expression, the authors confirmed the association between Lp(a) and aortic valve calcification in European, African-American and Hispanic-American cohorts. This finding reveals a potential candidate for targeted treatment of aortic stenosis, as well as providing an important insight into the potential role of Lp(a) in cholesterol transport and fibrinolysis in its pathogenesis.

• 出版日期2013-6