A simple, efficient and green procedure for the Knoevenagel condensation of aldehydes with N-methylpiperazine at room temperature under solvent-free conditions

作者：Mukhopadhyay Chhanda^*; Datta Arup

来源：Synthetic Communications, 2008, 38(13): 2103-2112.

DOI：10.1080/00397910802029364

• active methylene compounds
• aldehydes
• Knoevenagel condensation
• N-methylpiperazine
• solvent-free conditions

Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions in the presence of N-methylpiperazine in excellent yields of the E-configured products.

• 出版日期2008