Alterations of corticostriatal plasticity by ammonium and rescue by green tea polyphenols

作者：Chepkova Aisa N; Sergeeva Olga A; Haas Helmut L^*

来源：Archives of Biochemistry and Biophysics, 2013, 536(2): 176-182.

DOI：10.1016/j.abb.2013.02.002

• Ammonium
• Striatum
• NMDA
• Long-term potentiation
• Long-term depression
• Green tea polyphenols

Hyperammonemia is a major pathophysiological factor in encephalopathies associated with acute and chronic liver failure. On mouse brain slice preparations we analyzed the effects of ammonium on the characteristics of corticostriatal long-term potentiation (LTP) induced by high-frequency electrical stimulation (HFS) of cortical input and the long-lasting effects of pharmacological NMDA receptor (NMDAR) activation. Ammonium chloride exposure enhanced the expression of HFS-induced LTP at the expense of LTD and promoted the generation of NMDA-induced LTD. This treatment did not affect two NMDAR-independent forms of plasticity: taurine-induced LTP and histamine-induced LTD. Alterations in NMDA-induced plasticity were prevented by treatment with green tea polyphenols suggesting the contribution of oxidative stress to the expression of abnormal corticostriatal plasticity.

• 出版日期2013-8-15