Appreciating force and shape - the rise of mechanotransduction in cell biology

作者:Iskratsch Thomas; Wolfenson Haguy; Sheetz Michael P*
来源:Nature Reviews Molecular Cell Biology, 2014, 15(12): 825-833.
DOI:10.1038/nrm3903

摘要

Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility - for example, during cell matrix adhesion development - through the signalling process of mechanotransduction.

  • 出版日期2014-12