INHIBITION OF ESTROGEN-RECEPTOR ACTION BY A NATURALLY-OCCURRING VARIANT IN HUMAN BREAST-TUMORS

作者：FUQUA SAW; FITZGERALD SD; ALLRED DC; ELLEDGE RM; NAWAZ Z; MCDONNELL DP; OMALLEY BW; GREENE GL; MCGUIRE WL

来源：Cancer Research, 1992, 52(2): 483-486.

It is fairly well accepted that the presence of estrogen receptor (ER) and progesterone receptor (PgR) identifies breast cancer patients with a lower risk of relapse and better overall survival. But patients with discordant receptors, the ER+/PgR- phenotype, are often intermediate in clinical response. We focused upon this group of patients and have identified a truncated ER which is abundant in some ER+/PgR- breast tumors and which inhibits the binding of wild-type ER to its cognate response element. This variant interferes in a dominant negative manner with wild-type ER function and may represent a mechanism for modulation of estrogen responsiveness.

• 出版日期1992-1-15