Novel insights into the function of beta-cell M-3 muscarinic acetylcholine receptors: therapeutic implications

作者：de Azua Inigo Ruiz; Gautam Dinesh; Guettier Jean Marc; Wess Juergen^*

来源：Trends in Endocrinology and Metabolism, 2011, 22(2): 74-80.

DOI：10.1016/j.tem.2010.10.004

Impaired function of pancreatic beta-cells is one of the hallmarks of type 2 diabetes. beta-cell function is regulated by the activity of many hormones and neurotransmitters, which bind to specific cell surface receptors. The M-3 muscarinic acetylcholine receptor (M3R) belongs to the superfamily of G protein-coupled receptors and, following ligand dependent activation, selectively activates G proteins of the G(q/11) family. Recent studies with M3R mutant mice strongly suggest that beta-cell M3Rs play a central role in promoting insulin release and maintaining correct glucose homeostasis. In this review, we highlight recent studies indicating that beta-cell M3Rs and components of downstream signaling pathways might represent promising new targets for the treatment of type 2 diabetes.

• 出版日期2011-2