Usefulness of a simple sleep-deprived EEG protocol for epilepsy diagnosis in de novo subjects

作者：Giorgi Filippo S^*; Perini Daria; Maestri Michelangelo; Guida Melania; Pizzanelli Chiara; Caserta Anna; Iudice Alfonso; Bonanni Enrica

来源：Clinical Neurophysiology, 2013, 124(11): 2101-2107.

DOI：10.1016/j.clinph.2013.04.342

• Electroencephalogram
• Sleep deprivation
• Epilepsy
• Epileptic interictal abnormalities
• Sleep/wake cycle

Objective: In case series concerning the role of EEG after sleep deprivation (SD-EEG) in epilepsy, patients%26apos; features and protocols vary dramatically from one report to another. In this study, we assessed the usefulness of a simple SD-EEG method in well characterized patients. %26lt;br%26gt;Methods: Among the 963 adult subjects submitted to SD-EEG at our Center, in the period 2003-2010, we retrospectively selected for analysis only those:(1) evaluated for suspected epileptic seizures; (2) with a normal/non-specific baseline EEG; (3) still drug-free at the time of SD-EEG; (4) with an MRI analysis; (5) with at least 1 year follow-up. SD-EEG consisted in SD from 2:00 AM and laboratory EEG from 8:00 AM to 10:30 AM. We analyzed epileptic interictal abnormalities (IIAs) and their correlations with patients%26apos; features. %26lt;br%26gt;Results: Epilepsy was confirmed in 131 patients. SD-EEG showed IIAs in 41.2% of all patients with epilepsy, and a 91.1% specificity for epilepsy diagnosis; IIAs types observed during SD-EEG are different in generalized versus focal epilepsies; for focal epilepsies, the IIAs yield in SD-EEG is higher than in second routine EEG. %26lt;br%26gt;Conclusions: This simple SD-EEG protocol is very useful in de novo patients with suspected seizures. Significance:This study sheds new light on the role of SD-EEG in specific epilepsy populations.

• 出版日期2013-11