A new treatment for cognitive disorders related to in utero exposure to alcohol(star star star)star

作者：Li, Shuang; Zhang, Yan; Zhu, Feng; Zhang, Bin; Lin, Jianying; Xu, Chunyang; Yang, Wancai; Hao, Wei; Zhang, Ruiling^*

来源：Neural Regeneration Research, 2013, 8(18): 1702-1713.

DOI：10.3969/j.issn.1673-5374.2013.18.008

• neural regeneration
• neurogenesis
• pregnancy
• ethanol
• hippocampus
• development
• offspring
• learning and memory
• cyclin-dependent kinase 5
• grants-supported paper
• neuroregeneration

Maternal alcohol consumption during pregnancy has detrimental effects on fetal central nervous system development. Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin-dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory. In this study, we examined adult offspring in a maternal alcohol consumption model in rats. Y-maze test results showed that in utero exposure to alcohol impairs learning and memory capacities. Cyclin-dependent kinase 5 mRNA and protein expressions in the hippocampus of the offspring were significantly elevated, as assayed by quantitative real-time PCR and reverse transcription-PCR, immunofluorescence, and immuno-precipitation. Our experimental findings strongly suggest that altered cyclin-dependent kinase 5 may mediate impaired learning and memory in adult rats that were exposed to alcohol by maternal consumption while in utero.

• 出版日期2013-6
• 单位新乡医学院