Mapping the Epigenetic Basis of Complex Traits

作者：Cortijo Sandra; Wardenaar Rene; Colome Tatche Maria; Gilly Arthur; Etcheverry Mathilde; Labadie Karine; Caillieux Erwann; Hospital Frederic; Aury Jean Marc; Wincker Patrick; Roudier Francois; Jansen Ritsert C; Colot Vincent^*; Johannes Frank

来源：Science, 2014, 343(6175): 1145-1148.

DOI：10.1126/science.1248127

Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstrate that several of these differentially methylated regions (DMRs) act as bona fide epigenetic quantitative trait loci (QTL(epi)), accounting for 60 to 90% of the heritability for two complex traits, flowering time and primary root length. These QTL(epi) are reproducible and can be subjected to artificial selection. Many of the experimentally induced DMRs are also variable in natural populations of this species and may thus provide an epigenetic basis for Darwinian evolution independently of DNA sequence changes.

• 出版日期2014-3-7
• 单位中国地震局