A molecularly imprinted polymer for solid phase extraction of allantoin

作者：Zhong, Xianwen; Deng, Fang; Wang, Yuehua^*; Luo, Xubiao

来源：Microchimica Acta, 2013, 180(15-16): 1453-1460.

DOI：10.1007/s00604-013-1087-3

• Surface imprinting technique
• Allantoin
• Solid phase extraction
• Selectivity

We describe a molecularly imprinted polymer (MIP) for the solid-phase extraction of the skin protectant allantoin. The MIP was deposited on the surface of monodisperse silica microspheres possessing acroyl groups on the surface (MH-SiO2). The resulting MIP microspheres (MH-SiO2@MIP) showed a 3.4-fold higher adsorption capacity and a 1.9-fold better selectivity for allantoin than the respective non-imprinted polymer (MH-SiO2@NIP). The monolayer adsorption capacities of the MH-SiO2@MIP and the MH-SiO2@NIP were calculated with the help of the Langmuir model and found to be 6.8 and 1.9 mgaEuro cent g(-1), respectively. Adsorption kinetics fit a pseudo-second order rate mechanism, with an initial adsorption rate of 1.44 for the MH-SiO2@MIP, and of 0.07 mgaEuro cent g(-1)aEuro cent min(-1) for the MH-SiO2@NIP. The material can be regenerated, and its adsorption capacity for allantoin remains stable for at least five regeneration cycles. It was successfully used as a sorbent for the selective solid-phase extraction of allantoin from Rhizoma dioscoreae.

• 出版日期2013-11
• 单位南昌航空大学