A solvent-free method for the direct synthesis of Cbz-protected beta-amino ketones using triphenylphosphine dibromide

作者：Buragohain Pori; Saikia Partha Pratim; Barua Nabin C^*

来源：Tetrahedron Letters, 2013, 54(27): 3562-3564.

DOI：10.1016/j.tetlet.2013.04.105

• Multicomponent reaction
• Mannich reaction
• beta-Keto carbamate
• Solvent-free
• Triphenylphosphine dibromide

Triphenylphosphine dibromide (TPPDB) has been found to be a very effective catalyst for the one pot three-component Mannich reactions of aryl aldehyde, acetophenone, and benzyl carbamate under solvent-free condition at room temperature. The advantageous features of this methodology are operational simplicity, shorter reaction time, cost-effectiveness, and excellent yields. The catalyst possesses distinct advantages over other catalysts used for this conversion.

• 出版日期2013-7-3